An unbalanced scale depicting what happens when there are more anticoagulants than procoagulants.

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What is rebalancing in hemophilia?

Think of hemostasis as a scale, balanced between 2 sides—procoagulants Procoagulants: proteins that promote clotting. and anticoagulants. Anticoagulants: proteins that promote blood flow.

In hemophilia, there are reduced procoagulants, which causes an imbalance of hemostasis in favor of anticoagulants.

Procoagulants and anticoagulants can balance each other out.

An unbalanced scale, with the text "In hemophilia, the scale tips toward bleeds due to too few procoagulants".

In hemophilia, the scale tips toward bleeding due to too few procoagulants.

A balanced scale, with the text "By removing an anticoagulant, the scale may be rebalanced".

By removing an anticoagulant, the scales may be rebalanced.

Add and remove the proteins to learn more

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Rethink. Rebalance.

This balance can happen in 1 of 2 ways—either adding procoagulants, or taking away anticoagulants.

Anticoagulants can prevent your blood from clotting inappropriately. There are a number of different types of anticoagulants that naturally exist in the body.

In order to restore hemostasis, rebalancing in hemophilia aims to inhibit certain anticoagulants. Several are being evaluated in ongoing clinical trials, including: